Polynucleotides can increase Collagen up to 47% in 23 days & help create a thicker & healthier epidermis with measured improvements of 52% in 23 days

What are Polynucleotides (PNs)?

The amazing natural potential of PNs to revitalise, regenerate and rejuvenate the skin has garnered substantial attention in the field of cosmetic medicine. Collagen synthesis, skin healing, and overall skin rejuvenation are all aided by this novel treatment that uses nucleotides, the building blocks of DNA and RNA. These highly purified DNA fragments are extracted from Salmon or Trout to bio-stimulate positive changes in the skin.
The use of PNs in regenerative medicine has been well established for decades in tissue repair, following traumatic injury or surgery.

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What can Polynucleotides treat?

  • Dull, dehydrated & course skin
  • Fine lines & wrinkles
  • Uneven pigmentation
  • Redness & Inflammation
  • Under eye dark circles, hollowness & dullness
  • Skin laxity, tone & elasticity
  • Acne scarring, Stretch marks & Surgical scarring
  • Hair loss

Advantages of Polynucleotide treatment

  • Suitable for men and women
  • Suitable for all Fitzpatrick skin types
  • Suitable for use all over the body including the under eye area, face, neck, décolleté, hands, arms, knees and abdomen area (areas of skin laxity)

Benefits of Polynucleotide treatment

  1. Enhanced Skin Healing, Cellular Turnover & Regeneration
    One of the main advantages of PN treatment, is its capacity to promote skin regeneration and healing. PNs function at the cellular level and by increasing fibroblast activity, they encourage the synthesis of collagen and elastin. This enhances skin texture, tone, and elasticity, and increases the skin’s natural healing process and in turn aids in the regeneration of damaged tissues. Anti-inflammatory qualities of PNs can also assist in reducing redness and swelling following cosmetic operations or skin damage.
  1. Increased Skin Hydration and Moisture Retention
    Those with dry, dehydrated, or dull skin would benefit greatly from PNs exceptional moisturising qualities. PNs function by drawing and holding moisture to the skin which results in increased skin hydration and softer fine lines and wrinkles. The outcome is skin that is more supple, smoother, and plumper. PNs help reinforce the skin barrier, providing protection against environmental harm and minimising indications of ageing by enhancing the skin’s capacity to retain moisture.
  1. Collagen Synthesis and Skin Firmness
    The essential protein collagen gives the skin its structure and suppleness. Naturally, as we age, collagen production declines, causing wrinkles and loose drooping skin. Collagen synthesis is boosted with PN treatment, which encourages the skin to create new collagen fibres. In addition to improving skin texture and firmness, this helps reduce the visibility of wrinkles and fine lines. PNs encourage a more radiant, youthful complexion by increasing collagen levels.
  1. Reduction in Pigmentation and Scarring
    Age spots, sunspots, and melasma are examples of hyperpigmentation that PN treatment has helped in improving. The pigment known as melanin, which causes dark spots, is inhibited by PNs. A more even and luminous skin tone can be achieved using PNs by fading pre-existing pigmentation and preventing the development of new spots. Furthermore, by encouraging smoother and more even skin texture, PNs can help lessen the appearance of scars from acne and other forms of face scarring.

Polynucleotide Under Eye Treatment

Traditional tear trough dermal fillers mainly provide volume and depend on hyaluronic acid, which may result in chronic swelling and puffiness. However, the PN treatment takes a more comprehensive approach, improving the quality of the skin beneath the eyes by promoting the body’s own healing mechanisms instead of just ‘filling out’ the space with dermal filler.

As a result, PN treatment is the best under-eye treatment for addressing a variety of concerns related to ageing, lifestyle factors, or genetic predispositions, resulting in a radiant, brighter and revitalised eye area.


  • Reduces Dark Circles under the eyes
    PN treatment reduces the pigmentation and discoloration that contribute to the appearance of these dark circles
  • Improves Skin Elasticity under & around the eyes
    Loss of skin elasticity especially around the eyes is a common sign of ageing, leading to the formation of fine lines and wrinkles. PN treatment promotes greater skin elasticity, restoring a more youthful and supple appearance to the under eye area
  • Reduces the impact of under eye hollows
    Deep tear troughs under the eyes can create a tired and sunken look. PN treatment does not ‘fill’ these hollows like dermal filler but instead it subtly reduces the appearance of these under eye depressions by plumping and rejuvenating the skin in this area
  • Increases Cell Turnover & Improves micro-circulation
    PN treatment increases cell turnover, resulting in a fresher and more rejuvenated under-eye area
  • Protects Against Free Radical Damage
    PN treatment possesses antioxidant properties that help protect the under eye area from free radical damage hence promoting overall skin health
  • Improved Hydration under the eyes
    PN treatment stimulates higher hyaluronic acid synthesis, ensuring that the under-eye area remains hydrated and plump
  • Minimises Fine Lines and Wrinkles   
    The PN treatment stimulates collagen and elastin production improving skin elasticity and reducing the appearance of fine lines and wrinkles around the eyes leading to a smoother tone
  • Improves Skin Texture
    PN treatment can help reduce the appearance of roughness and unevenness, resulting in a refreshed and youthful look

Treatment Plan

During your consultation, you will be given detailed information about the procedure, the potential side effects and any pre- and post-treatment advice. You will also have time to decide whether or not, given the information, you would like to proceed with the treatment recommended.

Every patient will have a bespoke treatment plan, but for optimal results, we recommend 3 treatments initially (2-3 weeks apart) followed by 1 session every 6 months for maintenance.  Unlike Dermal filler treatment which offers instant results, PN treatment requires some patience and the best results are seen 2-3 months following treatment.

Procedure time (including consultation)


On set of results

Some changes can be noticed after the 1st treatment, however optimal results can be seen 60 days after the last session

Risks & Complications

Possible mild injection site swelling & bruising.

(Swelling usually subsides in 2 days & bruising disappears after 7 days)




Duration of results

6 months initially but this is accumulative with regular maintenance sessions


1 area: £250 per session

Course of 3 for 1 area: £650

(Price on consultation for 2 areas or more)

Results & Recovery time

As this is a regenerative treatment, the results are not instant but improvement can benoted from about three weeks and continues to improve over a twelve week period.

Patients report a general improvement in the radiance of the skin, feeling smoother and improved hydration. Pores, uneven colouration, texture, fine lines, wrinkles and scarring are reduced and softer in appearance. Additionally, PNs produce a mild increase in volume and tightening as an overall effect.

When hair loss is the concern being addressed, new hair growth can be noted and existing hair will be healthier.

Results will vary between individuals as the outcome is dependent upon the biological response of the individual and additional lifestyle factors.

Recovery time following this treatment is minimal and a relatively swift return to daily activities is possible. We do advise you not to have your treatment immediately prior to an important event as visible bumps may be present on your skin for 12-24 hours. However, temporary side effects include minor swelling, redness, bruising and tenderness and can take up to 2 days to resolve in some cases.

Can PN treatment be combined with other treatments?

Yes they can be combined. In fact it is recommended to combine with other treatments for optimal results.  Polynucleotide treatment is often paired with Anti wrinkle treatment, Dermal filler treatment, Fractional Radio Frequency, Profhilo or Micro-needling.

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*All of our treatments are bespoke for every individual and results may vary.  They require minimal downtime and any potential side effects will be discussed during your consultation.